Marinkovich Laboratory IN THE DEPARTMENT OF DERMATOLOGY

Novel extracellular matrix protein discovery:
laminin-311

laminin-311


The Marinkovich lab is focused on the discovery and characterization of extracellular matrix proteins in a variety of normal and malignant epithelial tissues. Laminin-311 (k-laminin) is one such example of such a protein which was isolated from conditioned keratinocyte medium and characterized. The figure shows purified laminin-311 analyzed by rotary shadowing electron microscopy in collaboration with Douglas Keene, Portland Shriners Hospital. This panel shows several individual laminin-311 molecules, illustrating its Y- like morphology.

 

References:

Tzu, J. and M. P. Marinkovich (2008). "Bridging structure with function: Structural, regulatory, and developmental role of laminins." Int J Biochem Cell Biol 40(2): 199-214.

Marinkovich, M. P., G. P. Lunstrum, D. R. Keene and R. E. Burgeson (1992). "The dermal-epidermal junction of human skin contains a novel laminin variant." J Cell Biol 119(3): 695-703.

 

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